We compared predation of artificial open-cup nests baited with Japanese Quail (Coturnix coturnix) eggs with predation of natural open-cup nests during 1997 and 1998 in a Louisiana pine forest to assess the assumption that predation of artificial nests is an index to that of natural nests. Cameras were placed at randomly selected natural and artificial nests in shrubs to document predators. Predation at artificial-nest plots was positively correlated with predation at adjacent natural-nest plots overall, although inconsistently by year. Artificial nests were almost exclusively depredated by corvids, but quail eggs were too large to be broken by small-mouthed mammalian predators. American Crows (Corvus brachyrhynchos) appeared to be important predators of natural nests. Predation of natural nests was independent of predation at other nests, but predation of artificial nests by crows was spatially and temporally clumped. Crows may have learned the location of artificial-nest plots, and predation of artificial nests increased significantly between years, contrary to predation of natural nests. Predation of artificial nests did not exhibit seasonal variation like that of natural nests. Overall, predation of artificial shrub nests did not accurately mimic that of natural shrub nests. Changes in procedures for artificial-nest studies that reduce spatially and temporally clumped predation and prevent the exclusion of small-mouthed predators could increase the suitability of such studies as a model for predation at natural nests. However, the difference in labor effort between studies of natural nests versus artificial nests that incorporate the changes we recommend likely would disappear, which would reduce the attractiveness of artificial-nest studies as an experimental model.